Steroid hormones and other steroid products

A steroid is a type of organic compound that contains a specific arrangement of four cycloalkane rings that are joined to each other. The core of the steroid molecule is composed of seventeen carbon atoms bonded together that take the form of four fused rings: three cyclohexane rings (designated as rings A, B, and C in the figure below) and one cyclopentane ring (the D ring). The steroids vary by the functional groups attached to the core structure and by the oxidation state of the rings. Methyl groups are normally present at C-10 and C-13. An alkyl side chain may also be present at C-17. Further, they vary by the configuration of the side chain, the number of additional methyl groups and the functional groups attached to the rings.

Steroids are numbered and rings are lettered as indicated in figure 1 below.

Schermafbeelding 2013-03-13 om 09.01.08

Steroids used for pharmaceutical purposes can be divided into various therapeutic categories:
  • Androgens are steroids that stimulate or control the development and maintenance of the male characteristics. This includes the activity of the male sex organs and the development of male secondary sex characteristics.
  • Estrogens are a group of steroid compounds, named for their importance in the estrous cycle, and functioning as the primary female sex hormone. Estrogens are used in some oral contraceptives, in estrogen replacement therapy for postmenopausal women, etc.
  • Progestogens are named for their function in maintaining pregnancy ('pro-gestational'), although they are also present at other phases of the estrous and menstrual cycles. Synthetic progestogens are usually referred to as 'Progestins'.
  • Corticosteroids are a class of steroid hormones that are produced in the adrenal cortex. Corticosteroids are involved in the regulation of inflammation, metabolism and behavior.
Steroid products produced by Aspen Oss are the following: 
 
• Androstanolone  (Dihydrotestosterone, Stanolone)
• Conjugated estrogens
• Desogestrel
• Esterified estrogens
• Estradiol
• Estradiol valerate
• Estriol
• Ethinyl estradiol
• Ethynodiol diacetate
• Nandrolone decanoate
• Norethindrone
• Norethindrone acetate
• Progesterone
• Rocuronium bromide
• Testosterone
• Testosterone cyclopentylpropionate
• Testosterone decanoate
• Testosterone isocaproate
• Testosterone phenylpropionate
• Testosterone propionate
• Testosterone undecanoate
• Tibolone