The majority of our API production activities are carried out at the Moleneind site, located in the heart of the city of Oss. At the Moleneind location we began our operations back in 1923, and still a lot of activities are performed here today. Apart from various chemical and biochemical factories, our Process Development and part of our Analytical Development laboratories are located at Moleneind. All Active Ingredients at this site are produced according to cGMP regulations; we hold a site-related GMP Certificate from the Dutch Ministry of Health.
The Diosite location of Aspen Oss was constructed in the 1990's. Since then De Geer has developed into a state-of-the-art API production location that contains:
- A modern, computer-directed, multi-purpose chemical factory used for larger production campaigns of various Active Ingredients (reaction vessels up to a volume of 10,000 liters).
- Modern API sieving, micronization and milling facilities.
- Clean-rooms and weighing chambers.
Sioux City (Iowa, USA)
Since many years, Aspen Oss runs a biochemical operation in Sioux City (Iowa, USA). In this facility, we collect porcine mucosa and produce a crude heparin, that is then transported to our facilities in Oss for final purification and product release. Having this Sioux City based facility in an important livestock area in the USA, provides close access to many large slaughterhouses, and thus to large mucosa quantities. Large-scale mucosa collection is indispensable to be able to continuously serve the world market needs for heparin sodium.